Modulation of adenylate cyclase response

Details Modulation of adenylate cyclase response Modulation of adenylate cyclase response

1988-12-27

1990-09-04

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

424600, 424722, 424724, 435184, C12N 988

Patent

active

049544489

ABSTRACT:
Silicic acid modulates (i.e. enhances or inhibits) adenylate cycloase activity. This effect appears to be a general one, inasmuch as the modulation has occurred in all tissues studied. The results suggest that silicic acid can be used in human and veterinary medicine to modulate hormone or neurotransmitter response. The results also indicate that silicic acid can be used to prevent, treat, or delay the onset of calcium-related bone disease, or to improve bone strength in an vertebrate having a bone strength less than desired.

REFERENCES:
Carlisle, "Silicon: A Requirement of Bone Formation Independent of Vitamin D" (1981) Calcif. Tissue Int. 33, 27-34.
Rude, "Skeletal Adenylate Cyclase: Effect of Mg.sup.+2, Ca.sup.2+ and PTH" (1985) Calcif. Tissue Int. 37:318-323.
Rude, "Renal Cortical Adenylate Cyclase Characterization of Magnesium Activation" (1983) Endocrinology, vol. 113, No. 4, 1348-1355.
Carlisle, "Silicon: An Essential Element for the Chick" (1972) Science, vol. 178, 619.
Carlisle "Silicon: A Possible Factor in Bond Calcification" (1970) Science, vol. 167, 279.
Cehc et al., "Adenylate Cyclase: The Role of Magnesium and Other Divalent Cations" (1980) Molecular and Cellular Biochemistry, 33, 67 92.

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