Modulating the interaction of the chemokine, B Lymphocyte Hemoat

Details Modulating the interaction of the chemokine, B Lymphocyte Hemoat Modulating the interaction of the chemokine, B Lymphocyte Hemoat

1997-12-02

2000-08-29

Fitzgerald, David L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 72, 435 721, 435 29, 424 851, G01N 3350, A61K 3819

Patent

active

06110695&

ABSTRACT:
The invention provides methods for identifying agents which modulate the interaction of a chemokine receptor of previously unknown function, Burkitt's Lymphoma Receptor 1 (BLR1), with its ligand, B Lymphocyte Chemoattractant (BLC). The methods find particular application in commercial drug screens.

REFERENCES:
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patent: 5919896 (1999-07-01), Lee et al.
WO 96 39522 A (Human Genome Sciences Inc; Li Haodong (US)) Dec. 12, 1996. See abstract. See p. 1, paragraph 2-p. 2, pargraph 3. See p. 24, paragraph 3-p. 25, paragraph 3. See examples 2,4,6. See claims 1-20. Seq. ID 4.
Forster, R., et al. (1986). A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87: 1037-47, Dec. 1996.
Legler, D.F., et al. (1998). B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J. Exp. Med. 187: 655-60, Feb. 1998.
Howard et al, TTBTECH 14, Feb. 1996, p. 46-51.
Hodgson, Bio/Technol 10, Sep. 1992, p. 973-77.
Wells et al, J. Leukocyte Biol. 59, Jan. 1996.

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