Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-03-01
2005-03-01
McKelvey, Terry (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C424S139100, C530S387100, C530S387900
Reexamination Certificate
active
06861228
ABSTRACT:
Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.
REFERENCES:
patent: WO-9210518 (1992-06-01), None
Rothberg et al., 1990, Genes & Devel. 4:2169-87.
Wilson et al., Nature, vol. 368: pp. 32-38. (Mar. 3, 1994).
Hillier et al., Locus AA055976 of the Embl-est58 and Genbank-est111 databases, unnumbered page (Feb. 1, 1997).
Hillier et al., Locus R78732 of the Embl-est58 and Genbank-est111 databases, unnumbered page (Jun. 9, 1995).
Brose Katja
Goodman Corey S.
Kidd Thomas
Tessier-Lavigne Marc
McKelvey Terry
The Regents of the University of California
Townsend and Townsend / and Crew LLP
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