Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2005-03-29
2005-03-29
Nickol, Gary (Department: 1642)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S019300
Reexamination Certificate
active
06872750
ABSTRACT:
The invention provides methods and compositions relating to Kuz involvement in angiogenesis. In various embodiments, the invention provides methods for modulating angiogenesis by specifically modulating the activity of Kuz in a vertebrate animal predetermined to have a pathogenic angiogenesis; methods for modulating angiogenesis by specifically modulating the activity of Kuz in a vertebrate animal and subsequently detecting a resultant angiogenic modulation in the animal; methods for specifically detecting Kuz activity in a vertebrate animal predetermined to have a pathogenic angiogenesis; methods for specifically detecting a pathogenic angiogenesis in a vertebrate animal having a predetermined Kuz activity; and methods for identifying a modulator of angiogenesis by (a) contacting an angiogenic assay system comprising a predetermined amount of Kuz with a candidate agent, under conditions whereby but for the presence of the agent, the system provides a reference angiogenesis; and (b) detecting an agent-biased angiogenesis of the system.
REFERENCES:
patent: 9808933 (1998-03-01), None
Galardy et al. (Cancer Res. 1994, vol. 54, No. 17, pp. 4715-4718).*
Fambrough et al., PNAS 1996 93:13233-38.
Pan et al., Cell 1997 90:271-80.
Wen et al. Development 1997 124:4759-67.
Pan Duojia
Rubin Gerald M.
Zhang Hongbing
Fetterolf Brandon
Nickol Gary
Osman Richard Aron
Regents of the University of California
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