Modular targeted liposomal delivery system

Details Modular targeted liposomal delivery system Modular targeted liposomal delivery system

2006-06-13

2006-06-13

Kishore, Gollamudi S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C424S001210, C424S009321, C424S009510, C424S417000

Reexamination Certificate

active

07060291

ABSTRACT:
A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound to the lipid bilayer, and the targeting moiety is covalently bound to the linking moiety. The liposome may also include a stabilizing moiety interposed between the linking and targeting moieties, and covalently bound to both. Alternatively, the stabilizing and targeting moieties may be covalently bound to separate linking moieties, the linking moieties being electrostatically bound to the lipid bilayer.

REFERENCES:
patent: 5534259 (1996-07-01), Zalipsky et al.
patent: 5935599 (1999-08-01), Dadey
patent: 6287857 (2001-09-01), O'Riordan et al.
Huang, A. et al., “Monoclonal Antibody Covalenty Coupled With Fatty Acid”, The Journal of Biological Chemistry, Sep. 10, vol. 255, No. 17, pp. 8015-8018.

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