Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-01-18
2005-01-18
Celsa, Bennett (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S091500, C530S324000, C530S350000
Reexamination Certificate
active
06844161
ABSTRACT:
Novel proteins and protein libraries are disclosed. The proteins possess one or more functional protein modules from different parent protein molecules. The proteins and protein libraries are exemplified by the preparation of cross-over chemokines that contain various combinations of peptide segments derived from RANTES, SDS-1 and vMIP-I and to vMIP-II. The proteins and libraries are extremely pure and can be provided in non-limiting high yields suitable for diagnostic and high-throughput screening assays.
REFERENCES:
patent: 5508261 (1996-04-01), Moyle et al.
patent: 6184344 (2001-02-01), Kent et al.
patent: 6326468 (2001-12-01), Kent et al.
patent: 0156588 (1985-10-01), None
patent: 0503683 (1992-09-01), None
patent: WO 9222368 (1992-12-01), None
patent: WO 9306844 (1993-04-01), None
patent: WO 9320098 (1993-10-01), None
patent: WO 9401102 (1994-01-01), None
patent: WO 9500846 (1995-01-01), None
patent: WO 9504543 (1995-02-01), None
patent: WO 9534641 (1995-12-01), None
patent: WO 9634878 (1996-11-01), None
patent: WO 9730161 (1997-08-01), None
patent: WO 9828434 (1998-07-01), None
patent: WO 9856807 (1998-12-01), None
Campbell, J.J. et al., “Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions,”Science(1998) 279:381-384.
Canne, L.E. et al., “Solid Phase Protein Synthesis by Chemical Ligation of Unprotected Peptide Segments in Aqueous Solution,” The 1997 American Peptide Symposium, Nashville, Tennessee, Jun. 14-19, 1997.
Cohen, J., “Exploiting the HIV-Chemokine Nexus,”Science(1997) 275:1261-1264.
Moore, P.S. et al., “Molecular Mimicry of Human Cytokine andCytokine Response Pathway Genes by KSHV,”Science(1996) 274:1739-1744.
Nord, K. et al., “Binding Proteins Selected from Combinatorial Libraries of an α-Helical Bacterial Receptor Domain,”Nature Biotechnology(1997) 15:772-777.
Siani, M.A. et al., “Rapid Modular Synthesis of Chemokines and Analogues,” Poster, pp. 1-13, International Business Communications 3rdAnnual International Conference on Chemokines, San Francisco, CA, USA, Sep. 30 -Oct. 1st, 1996.
Wilken, J. and Kent, S.B.H., “Chemical Protein Synthesis,”Curr. Opinions Biotechnol.(1998) 9:412-426.
Beall et al., “Site-directed mutagenesis of monocyte chemoattractant protein-1 identifies two regions of the polypeptide essential for biological activity,” Biochemistry (1996) 313:633-640.
Ben-Efraim et al., “Secondary structure and membrane localization of synthetic segments and a truncated from of the IsK (minK) protein,”Biochemistry(1994) 33:6966-6973.
Bleul et al. , “ The lymphocte chemoattractant SDF-1 is a ligand for LESTR/fusion and blocks HIV-1 entry,”Nature(1996) 382-829.
Boshoff et al., “Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines,” Science (1997) 278:290-294.
Brenner et al., “Encoded combinatorial chemistry,”Proc. Natl. Acad. Sci. U.S.A.(1992) 89:5381-5383.
Bunin et al., “The combinatorial synthesis and chemical and biological evaluation of a 1,4,-benzodiazepine library,”Proc. Natl. Acad. Sci. USA(1993) 91:4708-4712.
Canne et al., “Total chemical synthesis of a unique transcription factor-related protein—CMYC-MAX,”J. Am. Chem. Soc(1995) 117:2998-3007.
Canne et al., “A general method for the synthesis of thioester resin linkers for use in the solid phase synthesis of peptide-alpha-thioacids,”Tetrahedron Lett.(1995) 36:1217-1220.
Carrasco et al., “Direct monitoring of organic reactions on polymeric supports,” Tetrahedron Letters (1997) 38:6331-6334.
Clark-Lewis et al., “Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids,”J. Biol. Chem.(1994) 269:16075-16081.
Cwirla et al., “Peptides on phage: a vast library of peptides for identifying ligands,”Proc. Natl. Acad. Sci. USA(1990) 87:6378-6382.
Dawson et al., “Synthesis of proteins by native chemical Ligation,”Science(1994) 266:776-779.
Devlin et al., “Random peptide libraries: a source of specific protein binding molecules,”Science(1990) 249:404-406.
DeWitt et al., “Diversomers: an approach to nonpeptide, nonoligomeric chemical diversity,”Proc. Natl. Acad. Sci. U.S.A.(1993) 90:6909-6913.
Dos Remedios et al., “Fluorescence resonance energy transfer measurements of distances in actin and myosin,”J. Muscle Res. Cell Motility(1987) 8:97-117.
Fairclough and Cantor, “The use of singlet-singlet energy transfer to study macromolecular assemblies,”Meth. Enzymol.(1978) 48:347-379.
Furka et al., Abstr. 14th Int. Congr. Biochem., Prague, Czechoslovakia, vol. 5, p. 47. Abstr. 10th Intl. Symp. Med. Chem., Budapest, Hungary, (1988), p. 288.
Gaertner et al., “Site-specific religation of G-CSF fragments through a thioester bond,”Bioconj. Chem.(1994) 5(4) :333-338.
Gallop et al.,“Applications of combinatorial technologies to drug discovery, 1,”J. Med. Chem.(1994) 37:1233-1251.
Gauthier et al., “A new sensitive fluorogenic substrate for papain based on the sequence of the cystatin inhibitory site,”Arch. Biochem. Biophys.(1993) 306:304-308.
Geahlen et al., “A general method for preparation of peptides biotinylated at the carboxy terminus,”Anal. Biochem.(1992) 202:68-70.
Geysen et al., “Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid,” Proc. Nat. Acad. Sci. U.S.A. (1984), 81:3998-4002.
Gordon et al., “Applications of combinatorial technologies to drug discovery, 2,”J. Med. Chem.(1994) 37:1385-1401.
Houghten et al., “ General method for the rapid solid-phase synthesis of large number of peptides,”Proc. Natl. Acad. Sci. U.S.A.(1985) 82:5131-35.
Houghten et al., “Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery,”Nature(1991) 354:84-86.
Hromas et al., “Cloning and characterization of exodus, a novel beta-chemokine,”Blood(1997) 89(9): 3315-3322.
Lu et al., “Probing intermolecular main chain hydrogen bonding in serine proteinase-protein inhibitor complexes,”Biochemistry(1997) 36(4): 673-679.
Maggiora et al., “A general method for the preparation of internally quenched fluoregenic protease substrates using solid-phase peptide synthesis,”J. Med. Chem.(1992) 35:3727-3730.
Moos et al., “Recent advances in the generation of molecular diversity,”Annual Reports in Medicinal Chemistry(1993) 28:315-324.
Muir and Kent, “The chemical synthesis of proteins,”Curr. Opin. Biotechnology(1993) 4:420-427.
Needels et al., “Generation and screening of an oligonucleotide-encoded synthetic peptide library,”Proc. Natl. Acad. Sci. USA(1993) 90:10700-10704.
Neote et al., “Molecular cloning, functional expression and signaling characteristics of a C-C chemokine receptor,”Cell(1993) 72:415-425.
Oberlin et al., “The CXC chemokine SDF-1 is the ligand for LESTR/fusion and prevents infection by T-cell-line-adapted HIV-1,”Nature(1996) 382:833-835.
Oppenheim, “Overview of chemokines,”Adv. Exp. Med. Biol.(1993) 351:183-186.
Pavia et al., “The generation of molecular diversity,”Bioorganic and Medicinal Chem. Lett.(1993) 3:387-396.
Peled et al., “Synthetic S-2 and H-5 segments of the Shaker K♦channel: secondary structure, membrane interaction, and assembly within phospholipid membranes,”Biochemistry(1994) 33:7211-7219.
Proudfoot et al., “Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist,” J.B.C. (1996) 271:2599-2603.
Rajarathnam et al,. “Neutrophil activation by monomeric interleukin-8,”Science(1994) 264:90-92.
Schnölzer et al., “In situ neutralization in Boc-chemistry solid phase pe
Kent Stephen B. H.
Siani Michael A.
Simon Reyna
Wilken Jill
Auerbach Jeffrey I.
Celsa Bennett
Gryphon Therapeutics, Inc.
Liniak Berenato & White
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