Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-01-29
2008-01-29
Nashed, Nashaat T. (Department: 1656)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S231000, C435S252300, C435S320100, C536S023200
Reexamination Certificate
active
07323303
ABSTRACT:
A tool that can screen bacteria for β-lactamases against a panel of various antibiotics is desirable. A biosensor incorporating an indicator molecule into β-lactamases may achieve this purpose, but it requires that the attached indicator molecule must not impair the binding affinity of the protein to a great extent to provide a higher sensitivity. A modified β-lactamases with a residue on the Ω-loop or outside the Ω-loop but close to the active site of β-lactamase being replaced by a reactive residue is developed in this invention.
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Chan Pak-Ho
Leung Thomas Yun-Chung
Wong Kwok-Yin
Buchanan & Ingersoll & Rooney PC
Hong Kong Polytechnic University
Moore William W.
Nashed Nashaat T.
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