Modified α-MSH peptides and derivatives thereof

Details Modified α-MSH peptides and derivatives thereof Modified α-MSH peptides and derivatives thereof

2006-11-14

2006-11-14

Russel, Jeffrey Edwin (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C514S016700, C530S312000

Reexamination Certificate

active

07135548

ABSTRACT:
Novel peptides with antimicrobial activity are disclosed. The novel peptides are octomeric peptides modified from α-MSH. The modified α-MSH antimicrobial peptides disclosed herein may have enhanced activity against microbes over α-MSH due to modifications in peptide sequence and chirality of amino acids. Due an identified mechanism of action for antimicrobial activity in which cAMP accumulates in the microbial cell, it may be that microbes will not generate resistance to these modified α-MSH antimicrobial peptides.

REFERENCES:
patent: 6780838 (2004-08-01), Lipton et al.
patent: 6887846 (2005-05-01), Catania et al.
patent: 6939846 (2005-09-01), Lipton et al.
patent: WO 00/59527 (2000-10-01), None
Grieco et al. Novel alpha-Melanocyte Stimulating Hormone Peptide Analogues with High Candidacidal Activity. Journal of Medicinal Chemistry. Jan. 30, 2003, vol. 46, No. 5, pp. 850-855.
Sawyer et al. Structure-Activity Relationships of Nle4,DPhe7 alpha-MSH. Annals of the New York Academy of Sciences. 1993, vol. 680, pp. 597-599.

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