Modified vitamin K-dependent polypeptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, 514 8, 514 21, 514843, 424 9464, 424529, 435212, 435226, 435 696, 4352402, 536547, 536548, 536 232, 436 69, 530384, 530380, 530381, 530382, 530412, 530333, A61K 3836, A61K 3816, A61K 3814, C12N 1557

Patent

active

060178825

ABSTRACT:
The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.

REFERENCES:
patent: 5288629 (1994-02-01), Berkner
patent: 5504064 (1996-04-01), Morrissey et al.
patent: 5580560 (1996-12-01), Nicolaisen et al.
Li Zhang et al., "Role of Individual .gamma.-Carboxyglutamic Acid Residues of Activated Human Protein C in Defining its In Vitro Anticoagulant Activity", Blood, 80 (4), pp. 942-952 (1992).
Steven J. Freedman et al., "Identification of the Phospholipid Binding Site in the Vitamin K-dependent Blood Coagulation Protein Factor IX", Journal of Biological Chemistry, vol. 271, No. 27, pp. 16227-16236 (1996).
Jennifer V. Ratcliffe et al., "The Importance of Specific .gamma.-Carboxyglutamic Acids Residues in Prothrombin", Journal of Biological Chemistry, vol. 268, No. 32, pp. 24339-24345 (1993).
Egon Persson and Lars S. Nielsen, "Site-directed mutagenesis but not .gamma.-carboxylation of Glu-35 in factor VIIa affects the association with tissue factor", FEBS Letters, vol. 385, No. 3, pp. 241-243 (1996).
Amit M. Shah et al., "Manipulation of the membrane binding site of vitamin K-dependent proteins: Enhanced biological function of human factor VII", Proc. Natl. Acad. Sci. USA, vol. 95, pp. 4229-4234 (1998).
Smirnov et al., "A Chimeric Protein C Containing the Prothrombin Gla Domain Exhibits Increased Anticoagulant Activity and Altered Phospholipid Specificity", J. Biol. Chem., 1998, 273(15):9031-9040.
Perera et al., "Trans-Cis Isomerization of Proline 22 in Bovine Prothrombin Fragment 1: A Surprising Result of Structural Characterization", Biochem., 1998, 37:10920-10927.
Zhang et al., "The Contribution of Individual .gamma.-Carboxyglutamic Acid Residues in the Calcium-dependent Binding of Recombinant Human Protein C to Acidic Phospholipid Vesicles", J. Biol. Chem. 1993, 268(16):12040-12045.
Arnljots et al., J. Vasc. Surg., 25:341-346 (1997).
Kenneth A. Bauer, Haemostasis, 26:155-158, Suppl. 1 (1996).
Bjorn Dahlback, Blood, 85:607-614 (1995).
Evans et al., Protein Science, 5:suppl. 1, 163, Abstract (1996).
Fiore et al., J. Biol. Chem., 269:143-149 (1994).
Furie et al., Cell, 53:505-518 (1988).
Hedner et al., Transfus. Medi. Rev., 7:78-83 (1993).
Hope et al., Biochim. Biophys. Acta, 812:55-65 (1985).
Ching-hsien Huang, Biochemistry, 8:344-352 (1969).
Lu et al., Biochemistry, 35:8201-8209 (1996).
Matsubara et al., Dev. Biol., 180:499-510 (1996).
McDonald et al., Biochemistry, 36:5120-5127 (1997).
McDonald et al., Biochemistry, 36:15589-15598 (1997).
Nakagaki et al., Biochemistry, 30:10819-10824 (1991).
Nelsestuen et al., Biochemistry, 16(19):4164-4171 (1977).
Nicolaes et al., Thrombosis & Haemostasis, 76:404-410 (1996).
Nicolaisen et al., Thromb. Haemost., 76:200-204 (1996).
Petersen et al., Biochemistry, 29:3451-3457 (1990).
Rezaie et al., J. Biol. Chem., 267:26104-26109 (1992).
Schulman et al., Thromb. Haemost., 75:432-436 (1996).
Shen et al., Biochemistry, 36(51):16025-16031 (1997).
Sorensen et al., J. Biol. Chem., 272:11863-11868 (1997) p. 25 l 23
Thomsen et al., Thromb. Haemost., 70:458-464 (1993).
Valette et al., Nucleic Acids Res., 17:723-733 (1989).
Welsch et al, Biochemistry, 27:4939-4945 (1983).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Modified vitamin K-dependent polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modified vitamin K-dependent polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified vitamin K-dependent polypeptides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2315969

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.