Modified vaccinia virus and methods for making and using the sam

Details Modified vaccinia virus and methods for making and using the sam Modified vaccinia virus and methods for making and using the sam

1981-12-24

1988-09-06

Martinell, James

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 68, 435 91, 4351721, 435235, 435236, 4352401, 4352402, 435948, 935 32, 935 57, C12N 1500, C12N 700, C12N 704, C12N 500, C12P 2100, C12P 1934, C12R 191

Patent

active

047693304

ABSTRACT:
What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenic proteins, by said cells and host animals.

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