Modified vaccinia virus

Details Modified vaccinia virus Modified vaccinia virus

1982-12-08

1986-07-29

Rosen, Sam

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4351721, 4351722, 4351723, 424 89, C12N 700, C12N 1500

Patent

active

046031120

ABSTRACT:
What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenic proteins, by said cells and host animals.

REFERENCES:
Panicali et al., "Two Major DNA Variants etc.", J. Virol. 37(3), 1981, 1000-1010.
Weir et al., "Mapping of the Vaccinia Virus etc.", Proc. Nat'l. Acad. Sci. USA 79, 1982, 1210-1214.
Nakano et al., "Molecular Genetics of Vaccinia etc.", Proc. Nat'l. Acad. Sci. USA 79, 1982, 1593-1596.
Panicali et al., "Construction of Poxviruses etc.", Proc. Nat'l. Acad. Sci. USA 79, 1982, 4927-4931.
Mackett et al., "Vaccinia Virus etc.", Proc. Nat'l. Acad. Sci. USA 79, 1982, 7415-7419.
Smith et al., "Infectious Vaccinia Virus Recombinants etc.", Nature 302, 1983, 490-495.
Panicali et al., "Construction of Live Vaccines etc.", Proc. Nat'l. Acad. Sci. USA 80, 1983, 5364-5368.
Ensinger et al., "Marker Rescue etc.", J. Virol. 48(2); 1983, 419-428.
Smith et al., "Construction and Characterization etc.", Proc. Nat'l. Acad. Sci. USA 80, 1983, 7155-7159.
Jones et al., "Mapping of the Vaccinia Virus etc.", J. Virol. 49(1), 1984, 72-77.
Paoletti et al., "Construction of Live Vaccines etc.", Proc. Nat'l. Acad. Sci. USA 81, 1984, 193-197.
Mocarski et al.-Cell, vol. 22, (1980) p. 243.
Morse et al.-J. Virol., vol. 26, (1978) p. 389.
Bossart et al.-Chem. Abst., vol. 89, (1978) p. 56,251n.
Katz et al.-Chem. Abst., vol. 89, (1978) p. 39,241s.
Sam et al.-Ann. Virol., vol. 132E, (1981) pp. 135-150.
Wigler et al.-Cell, vol. 11, (1977) pp. 223-232.
Moss et al.-J. of Virology, vol. 40, No. 2, Nov. 1981, pp. 387-389, & 393-395.
Shigeru et al., C.A. 86 #3119g, 1977 of Yakugaku Zasshi (1976)96(10): 1247-1254, Protein Inhibitors of Gastric Acid Secretion Isolated From Vaccinia Virus-Infected Tissues.
Shigeru, C.A. 88 #55061t, 1978 of Japan Kokai 77116402, 29 Sep. 1977, Gastric Juice Secretion-Inhibiting Protein From Vaccinia Virus Infected Animal Tissues.
Nippon Zoki Pharm. C.A. 94 #7711g, (1981) of Jpn. Kokai Tokkyo Koho 8087724, 2 Jul. 1980, Selective Immune Enhancer.
Kruczek-Juszczyk C.A. 92 #126795f, (1980) of Ann. Univ. Mariae Curie Sect. C, 1978, 33: 1-8, Interferon Induction by Viral Nucleic Acids in Chick Embryo Fibroblasts.
Panicali et al., C.A. 94 #135967g, 1981 of J. Virol., 1981, 37(3): 1000-10, Two Major DNA Variants Present in Serially Propagated Stocks of the WR Strain of Vaccinia Virus.
Katz et al., C.A. 89 #39241s, (1978) of J. Antimicrob. Chemother. 1978 4(2): 159-162, Genetic Recombination Between Temperature Sensitive Mutant and IBT Resistant Mutant of Vaccinia Virus.
Chem. Abstracts, 10th Coll. Index, (1977-1981), vols. 86-95, Virus, Animal, Vaccinia Virus.

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