Modified urokinase having extended activity and method of making

Details Modified urokinase having extended activity and method of making Modified urokinase having extended activity and method of making

1980-05-05

1982-04-20

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435215, C12N 948, C12N 972

Patent

active

043260330

ABSTRACT:
Described is a structurally modified urokinase which is biologically active over an extended time period in comparison to native urokinase. The extended activity permits the administration of lower doses of urokinase when it is used in the treatment of thromboembolic diseases. Methods of appropriately modifying the structure of urokinase are described.

REFERENCES:
patent: 3930944 (1976-01-01), Nicol
patent: 3950223 (1976-04-01), Yugari et al.
patent: 4061538 (1977-12-01), Dorner et al.
patent: 4184917 (1980-01-01), Dorner et al.
Bose et al., Journal of Biological Chemistry, vol. 252, No. 23, pp. 8336-8337, Dec. 10, 1977.
Fujisawa et al., Journal of Biological Chemistry, vol. 253, pp. 8677-8679, Dec. 25, 1978.
Advances in Enzymology, vol. 41, pp. 99-128 (1974).

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