Modified tPA-containing injection composition having increased s

Details Modified tPA-containing injection composition having increased s Modified tPA-containing injection composition having increased s

1992-06-22

1995-06-20

Knode, Marian

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

424 9464, 435219, 435226, A61K 37547, C12N 950, C12N 964

Patent

active

054259436

ABSTRACT:
An injection composition comprises a pharmacologically effective amount of a modified tPA, 47.5 mM or more of an amino acid or a salt thereof and is improved in view of stability and solubility.

REFERENCES:
patent: 4244943 (1981-01-01), Yamahira et al.
patent: 4568544 (1986-02-01), Hasegawa et al.
patent: 4777043 (1988-10-01), Bennett et al.
patent: 4898826 (1990-02-01), Duffy et al.
patent: 4935237 (1990-06-01), Higgins et al.
patent: 4960702 (1990-10-01), Rice et al.
Van Zonneveld et al, J. Cell. Biochem 32:169-178 (1986).

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