Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1984-08-27
1988-06-28
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 91, 435253, 435212, 435215, 435320, 536 27, 935 10, 935 14, 935 29, 935 73, C12N 120, C12N 100, C07H 1700
Patent
active
047538791
ABSTRACT:
Modified human tissue plasminogen activators, the DNA sequences coding on expression for them and methods of making them in hosts transformed with those DNA sequences. The single chain form of these modified human t-PAs, t-PA (Lys 277.fwdarw.X), has a longer half life than the single chain form of native, or recombinant, t-PA, yet, in the two chain form these modified t-PAs have substantially the same affinity for fibrin and substantially the same activity as the two chain form of native, or recombinant, t-PA.
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Rosa Joseph J.
Rosa Margaret D.
Biogen N.V.
Haley, Jr. James F.
Huleatt Jayme A.
Pierri Margaret A.
Wiseman Thomas G.
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