Modified tissue plasminogen activator with modified glycosylatio

Details Modified tissue plasminogen activator with modified glycosylatio Modified tissue plasminogen activator with modified glycosylatio

1988-06-06

1993-09-14

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435212, 435219, 435226, 4352412, 4353201, 536 232, 524 9463, C12N 948, C12N 1558, C12P 2102, A61K 37547

Patent

active

052446760

ABSTRACT:
A modified t-PA having improved in vivo half-life is disclosed comprising in sequence a fibronectin finger-like domain F, a growth factor domain GF, a sequence of two K2 kringle regions and a serine protease region SP, wherein the first of said kringles is free of any glycosylation site and the second of said kringles has a single glycosylation site.

REFERENCES:
patent: 5149533 (1992-09-01), Mulvihill et al.
Harris, T. J. R., Protein Engineering, 1(6), pp. 449-458, 1987.
Gething, M. J. et al., EMBO Journal, 7(9): 2731-2740, 1988.
Pennica et al., Nature 301, 214-221 (1983).
Vehar, Bio/Technology 2(12), pp. 1051-1057 (1984).
Kagitani et al., FEBS Lett. 189(1), 145-149 (1985).
Zonneveld et al., Proc. Natl. Acad. Sci. USA 83, 4670-4 (1986).
Verheijen et al., The EMBO J. 5(13), 3525-3530 (1986).
Ehrlich et al., Fibrinolysis 1, 75-81 (1987).
Klausner, Bio/Technology 4, 706-711 (1986).
Klausner, Bio/Technology 5, 869-870 (1987).
Lau et al., Bio/Technology 5(9), 953-958 (1987).

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