Modified tissue plasminogen activator substituted at cysteine-73

Details Modified tissue plasminogen activator substituted at cysteine-73 Modified tissue plasminogen activator substituted at cysteine-73

1989-04-03

1991-08-06

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435219, 4353201, 4352402, 536 27, 935 14, 935 70, 935 23, 935 27, 424 9464, C12N 948, C12N 1558, C12P 2102, A61K 32547

Patent

active

050377523

ABSTRACT:
A modified tissue plasminogen activator having an improved in vivo half-life characterized in that the normal protein moiety of 527 amino acids is mutated at the site Cys73.fwdarw.Arg and at the site Lys277.fwdarw.Asp.

REFERENCES:
patent: 4963357 (1990-10-01), Bell
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Vehar, Bio/Technology 2(12), pp. 1051-1057 (1984).
Kagitani et al., FEBS Lett. 189(1), 145-149 (1985).
Zonneveld et al., Proc. Natl. Acad. Sci. USA 83, 4670-4674 (1986).
Verheijen et al., The EMBO J. 5(13), 3525-3530 (1986).
Ehrlich et al., Fibrinolysis 1, 75-81 (1987).
Klausner, Bio/Technology 4, 706-710 (1986).
Klausner, Bio/Technology 5, 869-870 (1987).
Lau et al., Bio/Technology 5(9), 953-958 (1987).

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