Modified tissue plasminogen activator K2K2SP

Details Modified tissue plasminogen activator K2K2SP Modified tissue plasminogen activator K2K2SP

1988-06-06

1992-03-31

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435212, 435219, 435226, 4352402, 4353201, 536 27, 424 9463, C12N 948, C12N 1558, C12P 2102, A61K 37547

Patent

active

051006669

ABSTRACT:
A modified t-PA having improved in vivo half-life is disclosed comprising in sequence a sequence of two K2 kringle regions and a serine protease region SP.

REFERENCES:
Gething, M. J. et al., The EMBO Journal, 7(9):2731-40, 1988.
Verstraete et al., Blood 67(6), 1529-1541 (Jun. 1986).
Pennica et al., Nature 301, 214-221 (1983).
Vehar, Bio/Technology 2(12), pp. 1051-1057 (1984).
Kagitani et al., FEBS Lett. 189(1), 145-149 (1985).
Zonneveld et al., Proc. Natl. Acad. Sci., USA 83, 4670-4 (1986).
Verheijen et al., The EMBO J. 5(13), 3525-3530 (1986).
Ehrlich et al., Fibrinolysis 1, 75-81 (1987).
Klausner, Bio/Technology 4, 706-710 (1986).
Klausner, Bio/Technology 5, 869-870 (1987).
Lau et al., Bio/Technology 5(9), 953-958 (1987).

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