Modified tissue plasminogen activator K2K2SP

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

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435212, 435219, 435226, 4352402, 4353201, 536 27, 424 9463, C12N 948, C12N 1558, C12P 2102, A61K 37547

Patent

active

051006669

ABSTRACT:
A modified t-PA having improved in vivo half-life is disclosed comprising in sequence a sequence of two K2 kringle regions and a serine protease region SP.

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Klausner, Bio/Technology 4, 706-710 (1986).
Klausner, Bio/Technology 5, 869-870 (1987).
Lau et al., Bio/Technology 5(9), 953-958 (1987).

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