Modified surfaces resistant to bacterial colonization

Details Modified surfaces resistant to bacterial colonization Modified surfaces resistant to bacterial colonization

1996-10-03

2000-01-25

Dudash, Diana

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

A61M 2500

Patent

active

060173343

ABSTRACT:
The present invention involves a surface having a coating consisting essentially of a polymer that is soluble in or hydrolyzable by water. When the surface is immersed in an aqueous medium, the coating slowly dissipates such that biological fouling of the surface is prevented or inhibited. Substances adhering to the surface of the slowly dissipating polymer are removed as the polymer dissipates. This dissipation may result from slow hydrolysis of the polymer, particularly if the polymer is a polyester or polyanhydride. Preferred polyesters include polylactide and polyglycolide. Polymers soluble in water include polyvinyl alcohol and polyethylene glycol. Such solubility must be sufficiently slow such that the surfaces may be coated and the water-soluble polymer remains for a long period of time and is slowly dissipated into solution. Such dissipation from the surface removes adherent substances. The adherent substances may be bacteria, fungi, biomolecules or multicellular organisms. The surfaces treated include polyvinylchloride, other plastics, elastomers, metals or ceramics.

REFERENCES:
patent: 3106483 (1963-10-01), Kline et al.
patent: 4143015 (1979-03-01), Soeterik
patent: 4306563 (1981-12-01), Iwatschenko
patent: 4315505 (1982-02-01), Crandall et al.
patent: 4416028 (1983-11-01), Eriksson et al.
patent: 4603006 (1986-07-01), Sikes et al.
patent: 4654380 (1987-03-01), Makepeace
patent: 4687792 (1987-08-01), Russell et al.
patent: 4708765 (1987-11-01), Newman et al.
patent: 4957989 (1990-09-01), Saitoh
patent: 5004631 (1991-04-01), Humphries et al.
patent: 5019096 (1991-05-01), Fox, Jr. et al.
patent: 5049139 (1991-09-01), Gilchrist
patent: 5096488 (1992-03-01), Stovicek
patent: 5225120 (1993-07-01), Graiver et al.
patent: 5269770 (1993-12-01), Conway et al.
patent: 5429839 (1995-07-01), Gravier et al.
patent: 5444113 (1995-08-01), Sinclair et al.
patent: 5458653 (1995-10-01), Davidson
patent: 5476509 (1995-12-01), Keogh et al.
patent: 5494660 (1996-02-01), Hunter et al.
patent: 5569463 (1996-10-01), Helmus et al.
Dankert et al., "Biomedical Polymers: Bacterial Adhesion, Colonization, and Infection," CRC Critical Reviews in Biocompatibility, 2(3):219-301, 1986 (no month.
Sheu et al., "A Glow Discharge Treatment to Immobilized Poly(ethylene Oxide)/Poly(propylene oxide) Surfactants for Wettable and Non-Fouling Biomaterials," J Adhesion Sci Technol, 6(9):995-1009, 1992 (no month).
van Wachem et al., "Interaction of Cultured Human Endothelial Cells with Polymeric Surfaces of Different Wettabilities," Biomaterials, 6:403-408, Nov. 1985.

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