Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases
Patent
1992-05-29
1994-01-11
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Oxidoreductases
424 941, 435189, 530350, 530400, A61K 3750, A61K 3748, C12N 902, C07K 1500
Patent
active
052779084
ABSTRACT:
A method and compositions for reducing ischemic, inflammatory or septic injury in an animal that includes administration to the animal of an effective amount of a modified superoxide dismutase, wherein the modification comprises substituting a first amino acid residue located within 3-12 .ANG. of the active site of the superoxide dismutase with a second amino acid residue capable of reacting with a highly reactive nitrating species, such as nitronium ion, formed from the reaction of peroxynitrite and superoxide dismutase.
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Beckman Joseph S.
Ischiropoulos Haralambos
Smith Craig D.
Robinson Douglas W.
The UAB Research Foundation
Weber Susan M.
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