Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1993-09-24
1995-08-22
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514 25, 514 26, 514 33, 514 35, 514160, 514171, A61K 3578, A01N 6500, A01N 4304, A01N 4500
Patent
active
054438292
ABSTRACT:
Disclosed herein are modified saponins or fractions thereof obtainable by modification of a crude Quillaja saponaria extract or by modification of purified saponins obtainable from a crude Quillaja saponaria extract useful in pharmaceutical compositions for enhancing the transport of pharmacologically active substances across mucous membranes of an animal. Also disclosed are modified saponins having reduced irritability wherein the aldehyde group is reduced and the fatty acid moiety may be removed by hydrolysis. Also disclosed are pharmaceutical compositions comprising the modified saponins of the invention.
REFERENCES:
patent: 4335113 (1982-06-01), Combier et al.
patent: 4443432 (1984-04-01), Garabedian et al.
patent: 4548922 (1985-10-01), Carey et al.
patent: 4550022 (1985-10-01), Garabedian et al.
patent: 4938970 (1990-07-01), Hustead et al.
patent: 4985253 (1991-01-01), Fujioka et al.
patent: 5057540 (1991-10-01), Kensil et al.
patent: 5118676 (1992-06-01), Minaskanian et al.
patent: 5118692 (1992-06-01), Peck
patent: 5166139 (1992-11-01), Bombardelli et al.
patent: 5182258 (1993-01-01), Chiou
Whitmore et al., Relative Effects of Different Surfactants on Intestinal Absorption and the Release of Proteins and Phospholipide. . . , Journal of Pharmaceutical Pharmacology 31:277-283 (1979).
Moore, J. A. et al., "Delivery Systems for Recombinant Methionyl Human Growth", Delivery Systems for Peptide Drugs, Davis, S. S. et al. (eds.), pp. 317-329, Plenum Press New York (1986).
Moses et al., Insulin Administered Intranasally as an Insulin-Bile Salt Aerosol, Effectiveness and Reproducibility in Normal and Diabetic Subjects, Diabetes 32:1040-1047 (1983).
Pillion et al., Systemic Absorption of Insulin Delivered Topically to the Rat Eye, Investigative Opthalmology & Visual Science 32:3021-3027 (1991).
Longenecker et al., Effects of Sodium Taurodihydrofusidate on Nasal Absorption of Insulin in Sheep, Journal of Pharmaceutical Sciences 76:351-355 (1987).
Maitani et al., Intanasal Administration of .beta.-Interferon in Rabbits, Drug Design and Delivery 1:65-70 (1986).
Martin et al., Membrane Damage by Bile Salts: The Protective Function of Phospholipids, Journal of Pharmaceutical Pharmacology 31:754-759 (1981).
Kensil et al., Separation and Characterization of Saponins with Adjuvant Activity from Quillaja saponaria Molina Cortex, Journal of Immunology 146:431-437 (1991).
Kimura et al., Mechanisms of Toxicities of Some Detergents Added to a Diet and of the Ameliorating Effect of Dietary Fiber in the Rat, Journal of Nutrition Science Vitaminology 28:483-489 (1982).
Lee et al., Intranasal Delivery of Proteins and Peptides, BioPharm. 30-37 (Apr. 1988).
Hirai et al., Nasal Absorption of Insulin in Dogs, Diabetes 27:296-299 (1978).
Hirai et al., Effect of Surfactants on the Nasal Absorption of Insulin in Rats, International Journal of Pharmaceutics 9:165-172 (1981).
Hirai et al., Mechanisms for the Enhancement of the Nasal Absorption of Insulin by Surfactants, International Journal of Pharmaceutics 9:173-184 (1981).
Higuchi et al., Structures of Compounds Derived from the Acyl Moieties of Quillajasaponin, Phyto-chemistry 26:2357-2360 (1987).
Higuchi et al., An Acylated Triterpenoid Saponin from Quillaja Saponaria, Phytochemistry 27:1165-1168 (1988).
Higuchi et al., Structure of Desacylsaponins Obtained from the Bark of Quillaja Saponaria, Phytochemistry 26:229-235 (1987).
Chiou et al., Improvement of Systemic Absorption of Insulin through Eyes with Absorption Enhancers, Journal of Pharmaceutical Sciences 78:815-818 (1989).
Chiou et al., Reduction of Blood Glucose Concentration with Insulin Eye Drops, Diabetes Care 11:750-751 (1988).
Chiou et al., Systemic Delivery of Insulin through Eyes to Lower the Glucose Concentration, Journal of Ocular Pharmacology 5:81-91 (1989).
Wu, J. et al., "The Journal of Immunology," vol. 148(5), pp. 1519-1525, Mar. 1, 1992.
Kensil, P., et al., "The FASEB Journal, " abstracts, #2190, p. A2071, Jun. 4-7, 1990 (abs).
Kensil, C. R. et al., Structure/Function Relationship in Adjuvants from Quillaja saponaria Molina, in Vaccines 92, F. Brown et al. (ed.), 1992 (pp. 35-40).
Maharaj, I. et al., Immune Responses of Mice to Inactivated Rabies Vaccine Administered Orally: Potentiation by Quillaja saponin, Can. J. Microbiol. 32: 414-420 (1986).
Kensil Charlotte A.
Marciani Dante J.
Soltysik Sean
Cambridge Biotech Corporation
Knode Marian C.
Larson Kristin K.
LandOfFree
Modified saponins isolated from Quillaja saponaria does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified saponins isolated from Quillaja saponaria, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified saponins isolated from Quillaja saponaria will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2140349