Modified ribozymes

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435 6, 435 9131, 4351723, 4353201, 435325, 435366, 536 231, 536 232, 536 245, A61K 4800, C12Q 168, C12N 1585

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058176357

ABSTRACT:
The claimed invention is drawn to RNA molecules with catalytic activity comprising at least one modified nucleoside having a modifier group replacing the hydroxy group at the 2'-position of the ribose sugar where the modifier group is an halo, amino, mono- or disubstituted amino, or an azido group, and methods of use in vivo.

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