Modified release matrix formulation of cefaclor and cephalexin

Details Modified release matrix formulation of cefaclor and cephalexin Modified release matrix formulation of cefaclor and cephalexin

1997-12-17

1999-09-07

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424499, 424488, 514964, A61K 922, A61K 4738

Patent

active

059484403

ABSTRACT:
A pharmaceutical composition in the form of a tablet for controlled release of an active ingredient comprises cefaclor, cephalexin, or their pharmaceutically acceptable hydrates, salts, or esters as active ingredient, and a mixture of hydrophilic polymers of different viscosity grades selected from the group consisting of at least one hydroxypropyl methylcellulose and at least one hydroxypropylcellulose. The composition optionally also contains one or more of a water soluble or water dispersible diluent. The quantities of the hydrophilic polymers and water soluble or water dispersible diluent are such that the therapeutically effective active ingredient is released at a rate suitable for twice daily administration of the pharmaceutical composition to human subjects. The tablets may also be coated with a rapidly dissolving water soluble polymeric film coat. In a preferred embodiment, the composition comprises about 50% to about 90% by weight of cefaclor, cephalexin, or their pharmaceutically acceptable hydrates, salts, or esters, and about 5% to about 35% of a mixture of hydrophilic polymers of different grades, wherein the hydrophilic polymers comprise about 0.1% to about 20% by weight of hydroxypropyl methylcellulose and about 0.1% to about 20% by weight of hydroxypropyl cellulose.

REFERENCES:
patent: 3065143 (1962-04-01), Christenson et al.
patent: 4250166 (1981-02-01), Maekawa et al.
patent: 4259314 (1981-03-01), Lowey
patent: 4369172 (1983-01-01), Schor et al.
patent: 4557925 (1985-12-01), Lindahl et al.
patent: 4704285 (1987-11-01), Alderman
patent: 4713247 (1987-12-01), Sakamoto et al.
patent: 4734285 (1988-03-01), Alderman
patent: 4756911 (1988-07-01), Drost et al.
patent: 4762951 (1988-02-01), Panoz et al.
patent: 4795327 (1989-01-01), Gaylord et al.
patent: 4871548 (1989-10-01), Edgren et al.
patent: 4919938 (1990-04-01), Lovegrove et al.
patent: 4968508 (1990-11-01), Oren et al.
patent: 4983398 (1991-01-01), Gaylord et al.
patent: 5051262 (1991-09-01), Panoz et al.

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