Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1989-02-02
1990-05-22
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424468, 424469, 424470, 424499, 424501, A61K 916
Patent
active
049276395
ABSTRACT:
A disintegratable formulation of gemfibrozil providing both immediate and sustained release and comprises a tablet compressed from a mixture of a first and second granulation, and a disintegration excipient operable to effect partial or complete disintegration in the stomach. The first granulation comprises finely divided particles of pure gemfibrozil granulated with at least one cellulose derivative and the second granulation comprises finely divided particles of pure gemfibrozil granulated with a pharmaceutically acceptable water soluble or insoluble polymer which are then uniformly coated with a pharmaceutically acceptable (meth)acrylate copolymer prior to admixture with the first granulation. The first and second granulations are present in the final composition in a ratio of from about 10:1 to about 1:10.
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Ghebre-Sellassie Isaac
Gordon Robert H.
Khan Sadath U.
Page Thurman K.
Warner-Lambert & Company
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