Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Solid support and method of culturing cells on said solid...
Reexamination Certificate
2004-12-13
2009-10-27
Ford, Allison M (Department: 1651)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Solid support and method of culturing cells on said solid...
C435S395000, C435S397000
Reexamination Certificate
active
07608455
ABSTRACT:
A modified reconstituted extracellular matrix composition is provided herein. The composition includes an extracellular matrix and at least one exogenous component selected from heparin, fibronectin and laminin. The composition may have a basic pH. Additionally, provided herein is a cell culturing system including a substrate and a coating thereon of the composition to assess potential stimulators and/or inhibitors for their effects on various cell cultures while increasing the signal dynamic range.
REFERENCES:
patent: 4829000 (1989-05-01), Kleinman et al.
patent: 5260210 (1993-11-01), Rubin et al.
patent: 5405772 (1995-04-01), Ponting
patent: 5629287 (1997-05-01), Brown et al.
patent: 5643787 (1997-07-01), Barsky et al.
patent: 5731417 (1998-03-01), Swiderek et al.
Schneider et al, Clinical Materials, 1993, vol. 13, pp. 51-55.
Kleinman et al, Analytical Biochemistry, 1987, vol. 166, pp. 1-13.
Schneider et al, Thrombosis and Haemostasis, 1997, vol. 78, pp. 1392-1398.
DiMilla et al, Journal of Cell Biology, 1993, vol. 122, No. 3, pp. 729-737.
Kedeshian et al, Cancer Letters, 1998, vol. 123, pp. 215-226.
Invitrogen's “DMEM Dulbecco's Modified Eagle Medium” Product Description (3 Pages), retrieved from lnvitrogen website on Jun. 29, 2006 http://www.invitrogen.com/content/sfs/ProductNotes/—DMEM%20-RD-MKT-HL050602.pdf?ProductNotelD=22.
Invitrogen's “Technical Resources- Media Formulations: DMEM” (1 Page), retrieved from Invitrogen website on Jun. 29, 2006 http://www.invitrogen.com/content.cfm?pagelD=95&fusaction=MediaForm.dsp—mediaForm&productID=50.
“Fibronectin from bovine plasma” Product Information Sheet, Sigma-Aldrich; retrieved from Online Product Catalog (URL: <http://www.sigmalaldrich.com/catalog/search/ProductDetail/SIGMA/F1141> on May 10, 2007 (2 pages).
Kleinman et al, “Basement Membrane Complexes with Biological Activity” Biochemistry, 1986, vol. 25, pp. 312-318.
“Heparin Unit” The Online Medical Dictionary (2000). Retrieved Sep. 19, 2008 from URL:<http://cancerweb.ncl.ac.uk/cgi-bin/omd?Howell+unit>.
Kubota, Role of Laminin and Basement Membrane in the Morphological Differentiation of Human Endothelial Cells into Capillary-like Structures, The Journal of Cell Biology, Oct. 1988, pp. 1589-1598, vol. 107.
Nicosia, Fibronectin Promotes the Elongation of Microvessels During Angiogenesis In Vitro, Journal of Cellular Physiology, 1993, pp. 654-661, vol. 154.
Passaniti, A Simple, Quantitative Method for Assessing Angiogenesis and Antiagiogenic Agents Using Reconstituted Basement Membrane, Heparain, and Fibroblast Growth Factor, Laborabory Investigation, 1992, pp. 519-528, vol. 67, No. 4.
BD Biosciences, Product Specification Sheet—BD Matrigel TM Basement Membrane Mix, Online, Feb. 15. 2002, pp. 1-3.
Merrill, Poly(ethylene oxide) star molecules: Synthesis, characterizations and applications in medicine and biology, J. Biomater. Sci. Polymer. Edn., 1993, pp. 1-11, vol. 5, No. 1/2.
Mannuzza Frank J.
Wu Min
Becton Dickinson and Company
Ford Allison M
Hoffman & Baron LLP
LandOfFree
Modified reconstituted basement membrane composition for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified reconstituted basement membrane composition for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified reconstituted basement membrane composition for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4104244