Modified rapid expansion...

Details Modified rapid expansion... Modified rapid expansion...

2005-05-10

2005-05-10

Leffers, Gerry (Department: 1636)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S320100, C435S455000, C435S069100, C435S372000, C435S375000, C536S023100, C530S351000, C530S388850, C530S389600

Reexamination Certificate

active

06890753

ABSTRACT:
The present invention provides a modified rapid expansion method (termed “low-PBMC-REM” or “modified-REM”), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes, without using the large excesses of peripheral blood mononuclear cells (PBMC) or EBV-transformed lymphoblastoid cells (LCL) characteristic of high-PBMC-REM. Clonal expansions of greater than 500-fold can be achieved within a single stimulation cycle of about 8-14 days.

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