Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2005-04-05
2005-04-05
Killos, Paul J. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C514S120000, C514S121000
Reexamination Certificate
active
06875886
ABSTRACT:
The instant invention provides reagents and methods for diagnosis, detection and treatment of cancers (for example, prostate cancers). In particular, the invention provides methods to generate various functionalized PSMA ligands, and their uses in diagnosis, detection, imaging, and treatment of prostate cancers, especially those overexpressing PSMA.
REFERENCES:
patent: 5538866 (1996-07-01), Israeli et al.
patent: 5804602 (1998-09-01), Slusher et al.
patent: 5981209 (1999-11-01), Slusher et al.
patent: 6025344 (2000-02-01), Jackson et al.
patent: 6025345 (2000-02-01), Jackson et al.
patent: 6071965 (2000-06-01), Jackson et al.
patent: 6271245 (2001-08-01), Jackson et al.
patent: 6288046 (2001-09-01), Jackson et al.
patent: 6348464 (2002-02-01), Jackson et al.
patent: 6372726 (2002-04-01), Slusher et al.
patent: 6384022 (2002-05-01), Jackson et al.
patent: 6444657 (2002-09-01), Slusher et al.
patent: 6452044 (2002-09-01), Jackson et al.
patent: WO 9748399 (1997-12-01), None
patent: WO 9748400 (1997-12-01), None
patent: WO 9813046 (1998-04-01), None
patent: WO 98130046 (1998-04-01), None
patent: WO 9845257 (1998-10-01), None
patent: WO 9932887 (1999-07-01), None
patent: WO 02057222 (2002-07-01), None
Valiaeva et al J. Organic Chemistry, 2001, vol. 66 pp. 5146-5154.*
Tokutake et al, Bioorganic & Medicinal Chemistry, vol. 6, No. 10 pp. 1935-1953 (1998).*
Katoh et al, Bioorganic & Medicinal Chemistry, vol. 6 no 13, pp. 1437-1442 (1996).*
Berger, U.V. & Schwab, M.E. N-Acetylated Alpha-Linked Acidic Dipeptides may be Involved in Axon-Schwann Cell Signaling.J. Neurocytology25, 499-512 (1996).
Jackson, P.F. et al. Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated Alpha-Linked Acidic Dipeptidase.J. Med. Chem.39, 619-622 (1996).
Kozikowski, A.P. et al. Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Carboxypeptidase II (NAALADase).J. Med. Chem.44, 298-301 (2001).
Lange, P.H. ProstaScint Scan for Staging Prostate Cancer.Urology57, 402-406 (2001).
Nan, F. et al. Dual Function Glutamate-Related Ligands: Discovery of a Novel, Potent Inhibitor of Glutamate Carboxypeptidase II Possessing mGluR3 Agonist Activity.J. Med. Chem.43, 772-774 (2000).
Neale, J.H. et al. N-Acetylaspartylglutamate: The Most Abundant Peptide Neurotransmitter in the Mammalian Central Nervous System.J. Neurochem.75, 443-452 (2000).
Slusher, B.S. et al. Immunocytochemical Localization of the N-Acetyl-Aspartyl-Glutamate (NAAG) Hydrolyzing Enzyme N-Acetylated Alpha-Linked Acidic Dipeptidase (NAALADase).J. Compar. Neuro.315, 217-229 (1992).
Stauch, B.L. et al. The effects of N-acetylated alpha-linked acidic dipeptidase (NAALADase) inhibitors on [3H]NAAG catabolism in vivo.Neurosci. Letters100, 295-300 (1989).
Subasinghe, N. et al. Synthesis of Acyclic and Dehydroaspartic Acid Analogues of Ac-Asp-Glu-OH and Their Inhibition of Rat Brain N-Acetylated Alpha-Linked Acidic Dipeptides (NAALADipeptidase).J. Med. Chem.33, 2734-2744 (1990).
Beth Israel Deaconess Medical Center Inc.
Killos Paul J.
Reyes Hector M.
Ropes & Gray LLP
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