Modified pseudomonas exotoxin PE.sub.40

Details Modified pseudomonas exotoxin PE.sub.40 Modified pseudomonas exotoxin PE.sub.40

1997-04-14

1999-06-15

Kemmerer, Elizabeth

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530399, 530402, C07K 1400, C12N 1500

Patent

active

059123222

ABSTRACT:
Psuedomonas exotoxin 40 is modified by deleting or substituting one or more cysteine residues. Such a modified protein may be incorporated into a fusion protein with TGF.alpha.. The resulting fusion protein exhibits altered biological activities from unmodified TGF.alpha.-PE.sub.40, including decreased cell killing activity and increase receptor-binding activity.

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