Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1992-05-05
1993-01-19
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530363, 530380, 530387, 530403, 530405, 530406, 530408, 530409, 530807, 5303898, 5303889, 424 88, 435188, 435961, 435964, 436543, 436823, C07K 1702, C07K 1514, C12N 996, A61K 39385
Patent
active
051808153
ABSTRACT:
Modified proteins for carrying hapten are provided. These carriers are prepared by blocking the amino groups of the original protein and then introducing amino groups into the carboxyl groups of the original protein. The blocking groups may be eliminated at the later stage to regenerate the amino groups of the original protein. The modified protein or polypeptide carrier have the three-dimensional structures different from the original proteins so that they are used in immunoassay while carrying low molecular weight haptens without the fear of forming antibodies for the original proteins. The modified protein carrier may also be used in the passive agglutination immunoassay without the need of absorbing the anti-hapten antibodies by the hapten-carrying carriers.
REFERENCES:
patent: 4302386 (1981-11-01), Stevens
patent: 4493795 (1985-01-01), Nestor, Jr. et al.
Chu et al (1982) J. Immunol. Methods 55: 73-78.
Erlanger (1980) Methods Enzymol 70: 85-104.
Pesce et al (1986) J. Immunol Methods 87: 21-27.
Fuji Photo Film Co. , Ltd.
Kim Kay
Nucker Christine M.
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