Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-11-07
1998-12-08
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530384, 530350, 435 697, 435 691, 435219, 435471, A61K 3514
Patent
active
058470859
ABSTRACT:
Modified Protein C molecules have been made which substitute the gamma carboxylglutamic acid (Gla) region of another Vitamin K dependent protein, most preferably prothrombin, for the native region of the Protein C. A modified protein C molecules has been made which substitutes the gamma carboxyglutamic acid (Gla) region with the corresponding region of prothrombin. The modified or chimeric protein C has advantages over the wild-type protein C since it is less sensitive to inhibition by some natural antibody inhibitors of protein C (which would otherwise decrease the ability of the protein C to act as an anticoagulant) and which do not need the same cofactors or same amounts of cofactors, and can therefore be effective in patients with lowered levels of the cofactors such as protein S or the lipids present in elevated levels in platelets such as phosphatidyl ethanolamine (PE). The anticoagulant activity of the chimera was tested in normal and factor V Leiden plasma. The chimera was approximately ten times more effective in inhibiting factor V Leiden plasma clotting.
REFERENCES:
patent: 4968626 (1990-11-01), Foster et al.
patent: 5225537 (1993-07-01), Foster
Geng et al. (1995) Biochem. 34, pp. 8449-8457.
Yu et al. (1994) Biochem. 33, pp. 823-831.
Zhong et al. (1993) Biotechniques 15/5, pp. 874-878.
Degan et al. (1987) Biochem. 26, pp. 6165-6177.
Geng et al. (Aug. 26, 1996) Thromb. Haemostasis, 76/2, pp. 205-207.
Esmon Charles T.
Smirnov Mikhail D.
Longton Enrique D.
Oklahoma Medical Research Foundation
Wax Robert A.
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