Modified protease inhibitors, process for their preparation, and

Details Modified protease inhibitors, process for their preparation, and Modified protease inhibitors, process for their preparation, and

1984-07-06

1987-01-13

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3764, C07K 710

Patent

active

046364897

ABSTRACT:
The invention relates to novel, modified eglins B and C, to the preparation thereof, and to pharmaceutical compositions which contain these compounds. Compared with eglin B and C, the modification consists in a terminal shortening. The compounds of the invention can be prepared e.g. by limited enzymatic proteolysis of elgins or by peptide synthesis.

REFERENCES:
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Jui-Yoa Chang et al., Methods Enzymol 1983, 91, (Enzyme Structure Part I), pp. 41-48.
R. Knecht et al., Analytical Biochemistry 130, 65-71, (1983).
Molecular Endocrinology, New York, (1977), pp. 27-29, 32 I. MacIntyre Ed.

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