Modified poxviruses, including modified smallpox virus...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S199100, C424S093200, C424S159100

Reexamination Certificate

active

07025970

ABSTRACT:
The present invention provides recombinant poxviruses, such as vaccinia virus, that contain an integrated exogenous sequence, such as a foreign gene, encoding a prodrug converting polypeptide that can convert a prodrug to a drug that prevents virus replication or is otherwise toxic to the virus. The recombinant poxviruses can be suitable for use as vaccines. The invention also provides, among other things, methods of inhibiting virus replication, methods of vaccination and methods of treating vaccinated subjects showing signs or otherwise at risk for of vaccination-induced disease.

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patent: 5856153 (1999-01-01), Tiraby et al.
patent: 2003/0031681 (2003-02-01), McCart et al.
Mackett et al PNAS 79:7415-7419, 1982.
Metzger et al Journal of Virology 8423-8427, 1994.
McCart et al Gene Therapy 7:1217-1223, 2000.
Kesson et al Clinical Infectious Diseases 25:911-4, 1997.
Smith et al (PNAS 93:7955-79760, 1995).
Chakrabarti et al (PNAS 93:9810-9815, 1996).

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