Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1991-04-05
1994-03-01
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
930141, 424 852, 435 6952, 435 695, C07K 1300
Patent
active
052909174
ABSTRACT:
Novel polypeptides having a modified amino acid sequence of human interleukin 1.alpha. polypeptides in which a certain amino acid residue(s) in said amino acid sequence is(are) exchanged for other amino acid residue(s). Said polypeptides having no capacity of induction of production of prostaglandin E.sub.2 while maintaining other biological activities of human interleukin 1 such as activation of lymphocyte and being expected to be useful as a medicament.
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Zurawski, et al. (1986) Gene 49:61-68, Expression in Excherichia coli of Synthetic Human Interleukin-1.alpha. Genes Encoding the Processed Active Protein, Mutant Proteins, and .beta.-Galactosidase Fusion Proteins.
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Huang, et al. (1987) FEBS Lett. 223: 294-298, Muteins of Human Interleukin-1 that Show Enhanced Bioactivities.
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Fukui Toshikazu
Furuta Ryuji
Kawashima Hitoshi
Kotani Hirotada
Yamagishi Junichi
Dainippon Pharmaceutical Co., Ltd.
Draper Garnette D.
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