Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1995-04-25
2000-09-05
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
4241841, 4241921, 4242651, 4242691, 4242721, 435 691, 435 711, 435 697, 435 712, A61K 3900, A61K 39002, A61K 39015, C12P 2106
Patent
active
061139173
ABSTRACT:
A recombinant polypeptide comprising a polypeptide which has added thereto a glycoxyl-phosphatidylinositol anchor structure, said polypeptide demonstrating a greater immune response than the corresponding polypeptide without the anchor. The polypeptide may be a parasite antigen such as a Plasmodium falciparum polypeptide. Recombinant vectors comprising the DNA sequence encoding the polypeptide with a glycolipid anchor addition sequence and host cells based thereon are also disclosed as well as vaccines and methods of inducing an immune response based on the polypeptides.
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Reymond, et al., "Anchoring of an Immunogenic Plasmodium falciparum Circumsporozoite Protein on the Surface of Dictyostelium discoideum", The Journal of Chemistry, vol. 270, No. 21, May 26, 1995, pp. 12941-12947.
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Fasel Nicolas Joseph
Reymond Christophe Dominique
Housel James C.
RMF Dictagene S.A.
Ryan V.
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