Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-11-20
1996-11-05
Walsh, Stephen G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530300, 435 691, A61K 3800, C07K 1400
Patent
active
055717918
ABSTRACT:
A cell lysis factor which is a modified fragment of the human glucocorticoid receptor. The modified fragment designated 398-465*, when transfected into and expressed in a host cell, effects cell lysis and cell death. A pharmaceutical composition having the modified fragment 398-465* or the encoded protein product may be used in treatment of proliferative diseases.
REFERENCES:
patent: 5468624 (1995-11-01), Thompson et al.
Thompson, "Apoptosis and Steroid Hormones," Molecular Endocrinology, 8(6):665-673 (1994).
Thompson, "Lymphoid Cell Apoptosis by Glucocorticoids: The Roles of C-MYC Down-Regulation and Glucocorticoid Receptor Domains," Clinical Endocrinology, 43(5):535-545 (1995).
Gigu ere et al., "Functional Domains of the Human Glucocorticoid Receptor," Cell, 46:645-652, 1986, published in USA.
Harbour et al., "Steroid Mediated Lysis of Lymhoblasts Requires the DNA Binding Region of the Steroid Hormone Receptor," J. Steroid Biochem., 35(1):1-9, 1990, published in USA.
Hollenberg et al., "Primary Structure and Expression of a Functional Human Glucocorticoid Receptor cDNA," Nature, 318:635-641, 1985, published in Europe.
Hollenberg et al., "Colocalization of DNA-Binding and Transcriptional Activation Functions in the Human Glucocorticoid Receptor," Cell 49:39-46, 1987, published in USA.
Nazareth et al., "Mapping the Human Glucocorticoid Receptor for Leukemic Cell Death," J. Biol. Chem., 266(26):12976-12980, 1991, published in USA.
Thompson et al., "Glucocorticoids in Maligant Lymphoid Cells: Gene Regulation and the Minimum Receptor Fragment for Lysis," J. Steroid Biochem. Molec. Biol., 41(3-8):273-282, 1992, published in Europe.
Nazareth et al., "Leukemic Cell Apoptosis Caused by Constitutively Active Mutant Glucocorticoid Receptor Fragments," Recent Progress in Hormone Research, Proceedings of the 1993 Laurentian Hormone Conference, 50:417-421, 1995.
Nazareth Lynne V.
Thompson E. Brad
Board of Regents , The University of Texas System
Teng Sally P.
Walsh Stephen G.
LandOfFree
Modified polypeptide fragments of the glucocorticoid receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified polypeptide fragments of the glucocorticoid receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified polypeptide fragments of the glucocorticoid receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2015230