Modified pollen grains for delivering biologically active substa

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants

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Details

424484, 424499, 424449, 424451, 424434, 424465, 424 91, 514 3, A61K 3726, A61K 950, A61K 31715, A01N 2534

Patent

active

050135520

ABSTRACT:
Loaded pollen grains are disclosed which are suitable for use as delivery systems for introducing biologically active substances into or on plants and animals. Such pollen grains are suitable to deliver both small and large (macromolecules) molecules. Preferred pollen grains are those that have been defatted and then pre-treated to be free of antigenic materials and that have special surface features that facilitate their attachment to tissue surfaces, particularly to mucous membranes. The most preferred pollen grains are those that have spiny or irregular or fragmented surfaces. Also disclosed are a method of pre-treating the pollen grains to remove antigenic materials; a method of loading the pollen grains with the biologically active material; and a method of incorporating such pre-treated, loaded pollen grains into formulations or dosage forms suitable for introduction into or on a plant or animal body.

REFERENCES:
patent: 2150131 (1937-05-01), Rockwell
patent: 2207415 (1938-01-01), Rosenwald
patent: 2500145 (1950-03-01), Ferguson
patent: 2669066 (1954-02-01), Antles
patent: 4426397 (1984-01-01), Schanze
patent: 4529612 (1985-07-01), Robson

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