Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-07-14
2009-06-23
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
07550479
ABSTRACT:
A method of introducing a second stereogenic center into a tetrahydro-β-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.
REFERENCES:
patent: 5859006 (1999-01-01), Daugan
patent: 6878711 (2005-04-01), Orme et al.
patent: 7098209 (2006-08-01), Orme et al.
patent: WO2002036593 (2002-05-01), None
P.D. Bailey et al.,J. Chem. Soc. Perkin Trans. 1, 431-39 (1993).
A. Madrigal et al.,Tetrahedron: Asymmetry, 11, 3515-26 (2000).
A. Ishida et al.,Chem. Pharm. Bull., vol. 3, 3237-49 (1985).
H. Wang et al.,Organic Letters, vol. 1, No. 10, 1647-49 (1999).
P.D. Bailey et al.,Tetrahedron Letters, vol. 28, No. 25, 2879-82 (1987).
P.D. Bailey et al.,Tetrahedron Letters, vol. 35, No. 21, 3587-88 (1994).
P.D. Bailey et al.,J. Chem. Soc., Chem. Commun., 1507-09 (1985).
P.D. Bailey et al.,J. Chem. Soc. Perkin Trans. 1, 739-45 (1988).
P.D. Bailey et al.,Tetrahedron Letters, vol. 28, No. 43, 5177-80 (1987).
P.D. Bailey et al.,J. Chem. Soc. Perkin Trans. 1, 451-58 (1993).
P.D. Bailey et al.,Tetrahedron Letters, vol. 32, No. 31, 3895-98 (1991).
P.D. Bailey et al.,J. Chem. Soc. Perkin Trans. 1, 441-49 (1993).
P.D. Bailey et al.,Tetrahedron Letters, vol. 35, No. 21, 3585-86 (1994).
P.D. Bailey et al.,J. Chem. Soc. Perkin Trans. 1, 1209-14 (1997).
P.D. Bailey et al.,Chem. Commun., 1479-80 (1996).
P.D. Bailey,Tetrahedron Letters, vol. 28, No. 43, 5181-84 (1987).
K.M. Czerwinski et al.,Tetrahedron Letters, vol. 33, No. 33, 4721-24 (1992).
F. Ungemach et al.,J. Org. Chem., 164-68 (1981).
W-M. Dai et al.,Tetrahedron Letters, vol. 37, No. 33, 5971-74 (1996).
L. Deng et al.,Tetrahedron Letters, vol. 32, No. 2, 175-78 (1991).
M.L. Trudell et al.,Tetrahedron, vol. 48, No. 10, 1805-22 (1992).
C. Gremmen et al.,Tetrahedron Letters, 39, 1441-44 (1998).
P. Zhang et al.,Tetrahedron Letters, vol. 36, No. 39, 6999-7002 (1995).
A. Ganesan, Recent Studies in Total and Combinatorial Synthesis, Department of Chemistry, University of Southampton, Undated.
Chelius Erik C.
Doecke Christopher W.
Martinelli Michael J.
Orme Mark W.
Pawlak Joseph M.
Lilly ICOS LLC
Murray Jeffrey H
Napoli James J.
Wilson James O
Wood Dan L.
LandOfFree
Modified Pictet-Spengler reaction and products prepared... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified Pictet-Spengler reaction and products prepared..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified Pictet-Spengler reaction and products prepared... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4055532