Organic compounds -- part of the class 532-570 series – Organic compounds – Acyclic carbon bonded directly to three benzene rings or to...
Patent
1995-05-08
1998-03-10
Ambrose, Michael G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Acyclic carbon bonded directly to three benzene rings or to...
549221, 585151, 585168, 585180, C07F 9655, C07F 9141, C07F 924, C07F 9146, C07F 942
Patent
active
057263299
ABSTRACT:
Phosphoramidites of the formula ##STR1## where R is a base-labile protecting group, R.sup.1 and R.sup.2 are individually alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, or aryl of 6 to 20 carbon atoms or are joined together to form with the nitrogen atom a cyclic structure of 4-7 carbon atoms and 0 to 1 annular chalcogen atoms of atomic number 8 to 16, G is a hydrocarbylene group of 1 to 20 carbon atoms and Z is a hydroxy-protected vicinal diol group bound to G by one of the vicinal diol carbon atoms or a disulfide group and bound to G by one of the sulfur atoms of the disulfide group, with the proviso that G is of at least 4 carbon atoms when Z is said disulfide group are used in conventional automated oligonucleotide synthesis to introduce a functional aldehyde or thiol group on the 5' end of the oligonucleotide to thereby provide a reactive site on the oligonucleotide that may be used to conjugate the oligonucleotide to molecules that contain a free amino group or an electrophilic center reactive with a thiol group.
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Conrad Michael J.
Coutts Stephen
Hachmann John P.
Jones David S.
Livingston Douglas Alan
Ambrose Michael G.
La Jolla Pharmaceutical Company
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