Modified phosphoramidite process for the production of modified

Details Modified phosphoramidite process for the production of modified Modified phosphoramidite process for the production of modified

1995-01-10

1997-12-23

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 243, 536 2433, 536 253, 536 2531, 536 2532, 536 2533, 536 2534, 435 911, C07H 100, C07H 2100

Patent

active

057009198

ABSTRACT:
The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.

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Jager et al., Biochemistry, 27, p. 7237 (1988).
Asseline et al., Nucleosides & Nucleotides, 7, p. 431 (1988).
Bannwarth et al., Tetrahedron Lett., 30, p. 1513 (1989).
Gait; Oligonucleotide synthesis, IRL Press, Oxford, 1984, pp. 34-39.
Hamamoto et al., Chemistry letters, 1986, pp. 1401-1404.

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