Modified phosphocalcic compound, injectable composition...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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C514S089000, C548S112000, C546S022000, C558S156000

Reexamination Certificate

active

08044037

ABSTRACT:
A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.

REFERENCES:
patent: 5208234 (1993-05-01), Poss
patent: 7521436 (2009-04-01), Bujoli et al.
patent: WO 00/47214 (2000-08-01), None
H. Denissen et al., “Ceramic hydroxyapatite implants for the release of bisphosphonate,”Bone and Mineral, 1994, pp. 123-134, vol. 25, No. 2, Elsevier Science Ireland Ltd., Shannon, Ireland, XP-001015353.
H. Denissen et al., “Alveolar Bone Response to Submerged Bisphosphonate-Complexed Hydroxyapatite Implants,”Journal of Periodontology, 2000, pp. 279-286, vol. 71, No. 2, US XP-008010275.
H. Denissen et al., “Net-shaped hydroxyapatite implants for release of agents modulating periodontal-like tissues,”Journal of Periodontal Research, 1997, pp. 40-46, vol. 32, No. 1, Denmark XP-008010473.
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Kostromina et al., 2001, CAS: 136:75305.
Cohen et al., 1998, CAS: 129:49620.
Zaheer et al., 2001, CAS: 136:163487.

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