Modified pertussis toxin

Details Modified pertussis toxin Modified pertussis toxin

2006-12-05

2006-12-05

Brusca, John S. (Department: 1631)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S240100

Reexamination Certificate

active

07144576

ABSTRACT:
The development of subunits and subunit analogs of theBordetellaexotoxin by recombinant DNA techniques provides vaccine products that retain their biological activity, are highly immunogenic, and can confer protection against disease challenge. Genetically-engineered modifications of the subunits can result in products that retain immunogenicity, yet are free of enzymatic activity associated with toxin of reactogenicity.

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