Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Chemical aftertreatment – e.g. – acylation – methylation – etc.
Patent
1991-09-27
1994-11-08
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Chemical aftertreatment, e.g., acylation, methylation, etc.
530328, 530405, 530406, 530409, 530410, 534 12, C07K 308, C07K 706
Patent
active
053628527
ABSTRACT:
A process is disclosed for site-directed chemical modification of peptides and proteins that consists of two steps; (a) selective oxidation of a 2-hydroxyethylamine moiety, --CH(NH.sub.2)--CH(OH)--, in the peptide or protein to generate an aidehyde, and (b) reaction of the new aldehyde with a second reagent to form a product in which the native biological properties of the peptide are augmented by new and useful properties conferred by the second reagent. Additionally, the invention pertains to certain specified types of product formed by the above process.
REFERENCES:
patent: 4973666 (1990-11-01), Eyre
patent: 5132111 (1992-07-01), Vale, Jr. et al.
Nature, vol. 312, issued 20 Nov. 1984, Lomedico et al., "Cloning and expression fo murine interleukin-1", pp. 458-462.
Eur. J. Biochem., vol. 134, 1983, Maassen et al., "Synthesis and Application of Two Reagents . . . ", pp. 327-330.
Ginsburg Paul H.
Pfizer Inc.
Richardson Peter C.
Russel Jeffrey E.
Sheyka Robert F.
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