Modified peptide derivatives and methods of use thereof

Details Modified peptide derivatives and methods of use thereof Modified peptide derivatives and methods of use thereof

2007-05-29

2007-05-29

Solola, Taofiq (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C560S158000, C436S086000

Reexamination Certificate

active

10461208

ABSTRACT:
The present invention relates to a compound of formula Iwherein(i) when a and c are double bonds, R2is absent, b is a single bond,R1isor(ii) when a and c are single bonds, b is a double bond, and R1is H,R2iswherein the substituents are as defined in the specification.

REFERENCES:
patent: 52-034530 (1977-09-01), None
patent: WO 96/14339 (1996-05-01), None
patent: WO 96/35715 (1996-11-01), None
patent: WO 97/11174 (1997-03-01), None
patent: WO 97/42222 (1997-11-01), None
patent: WO 98/25950 (1998-06-01), None
patent: WO 99/64574 (1999-12-01), None
Braaten, et al. Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. EMBO J. Mar. 15, 2001;20(6):1300-9.
Christner, et al. Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J Med Chem. Sep. 9, 1999;42(18):3615-22.
Gallo, et al. Specific interaction between cyclophilin and cyclic peptides. Biopolymers. Sep. 1995;36(3):273-81.
Kallen, et al. The X-ray structure of a tetrapeptide bound to the active site of human cyclophilin A. FEBS Lett. Apr. 6, 1992;300(3):286-90.
Taylor, et al. Structures of cyclophilin-ligand complexes. Prog Biophys Mol Biol. 1997;67(2-3):155-81.
Zhao, et al. Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes. Biochemistry. Jun. 11, 1996;35(23):7362-8.

Affiliated with

Also associated with

Rating

Modified peptide derivatives and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modified peptide derivatives and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified peptide derivatives and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3752312