Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2008-07-22
2008-07-22
Tsang, Cecilia (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C530S328000, C514S002600, C424S001690
Reexamination Certificate
active
10469655
ABSTRACT:
The invention provides a peptide based on biologically active CCK-8 having improved characteristics for the treatment of obesity and/or type 2 diabetes wherein the primary structure of CCK-8 is: Asp1Tyr2(SO3H)-Met3Gly4Trp5Met6Asp7Phe8amide (SEQ ID NO:1) and wherein the peptide has at least one amino add substitution and/or modification and is not Asp1-glucitol CCK-8. The invention also provides the use of the peptide in the preparation of a medicament to inhibit food intake, induce satiety, stimulate insulin secretion, moderate blood glucose excursions, enhance glucose disposal and/or exhibit enhanced stability in plasma compared to native CCK-8 and/or for treatment of obesity and/or type 2 diabetes.
REFERENCES:
patent: 5128448 (1992-07-01), Danho et al.
patent: 5631230 (1997-05-01), Fang et al.
patent: 6924264 (2005-08-01), Prickett et al.
patent: 18 00 129 (1969-05-01), None
patent: 19 35 402 (1970-01-01), None
patent: 276 482 (1990-02-01), None
M. Rodriguez et al., “Synthesis and biological activity of pseudopeptide analogues of the C-terminal heptapeptide of cholecystokinin. On the importance of the peptide bonds.”,Journal of Medicinal Chemistry30:8 (Aug. 1987) pp. 1366-1373, American Chemical Society. Washington.
M. Rodriguez et al., “Synthesis and biological activity of some partially modified retro-inverso analogues of cholecystokinin”, Journal of Medicinal Chemistry 32:10, pp. 2331-2339 (Oct. 1989) American Chemical Society, Washington.
R. Gonzalez-Muniz et al., “Solid phase synthesis of a fully active analogue of cholecystokinin using the acid-stable OC-Phe (p-CH2) SO3H as a substitute for Boc-Tyr (SO3H) in CCK8”,International Journal of Peptide and Protein Research, vol. 37, pp. 331-340 (1991) Munksgaard, Copenhagen, DK.
O'Harte, Finbarr P. M. et al., “Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymic degradation”,Diabetes47(10), 1619-1624 (1998).
M-C Galas et al., “Structure-Activity Relationship Studies On Cholecystokinin Analogues With Partial Agonist Activity”,American Journal of Physiology254:2 Part 1 (1988) pp. G176-G182.
Kuwahara A et al., “Effects Of Cholecystokinin Octapeptide On Gastric Motility Of Anesthetized Dogs”,American Journal of Physiology, 251:5 Part 1 (1986) pp. G678-G681.
Flatt Peter Raymond
O'Harte Finbarr Paul Mary
Audet Maury
Licata & Tyrrell PC
Tsang Cecilia
University of Ulster
LandOfFree
Modified peptide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified peptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified peptide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3932187