Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2008-07-22
2008-07-22
Tsang, Cecilia (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C530S328000, C514S002600, C424S001690
Reexamination Certificate
active
07402663
ABSTRACT:
The invention provides a peptide based on biologically active CCK-8 having improved characteristics for the treatment of obesity and/or type 2 diabetes wherein the primary structure of CCK-8 is: Asp1Tyr2(SO3H)-Met3Gly4Trp5Met6Asp7Phe8amide (SEQ ID NO:1) and wherein the peptide has at least one amino add substitution and/or modification and is not Asp1-glucitol CCK-8. The invention also provides the use of the peptide in the preparation of a medicament to inhibit food intake, induce satiety, stimulate insulin secretion, moderate blood glucose excursions, enhance glucose disposal and/or exhibit enhanced stability in plasma compared to native CCK-8 and/or for treatment of obesity and/or type 2 diabetes.
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R. Gonzalez-Muniz et al., “Solid phase synthesis of a fully active analogue of cholecystokinin using the acid-stable OC-Phe (p-CH2) SO3H as a substitute for Boc-Tyr (SO3H) in CCK8”,International Journal of Peptide and Protein Research, vol. 37, pp. 331-340 (1991) Munksgaard, Copenhagen, DK.
O'Harte, Finbarr P. M. et al., “Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymic degradation”,Diabetes47(10), 1619-1624 (1998).
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Flatt Peter Raymond
O'Harte Finbarr Paul Mary
Audet Maury
Licata & Tyrrell PC
Tsang Cecilia
University of Ulster
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