Modified p53 constructs which enhance DNA binding

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Nucleoproteins – e.g. – chromatin – chromosomal proteins,...

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435 691, 4353201, 536 234, 536 235, C07K 14435, C07K 1447, C12N 1512, C12N 1563

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058470832

ABSTRACT:
A modified p53 protein or peptide having DNA binding in which amino acid residue 284 of a p53 protein or protein fragment is changed to Arginine or Lysine, is described. Also described are nucleotide sequences encoding the modified protein and vectors capable of expressing it.

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