Modified OmpA signal sequence for enhanced secretion of polypept

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 694, 435 697, 4353201, 435 712, 536 235, 536 231, 530399, C12N 1511, C12N 1512

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054707196

ABSTRACT:
A signal peptide sequence and nucleic acids encoding this sequence which are useful for improving the secretion efficiency of NGF polypeptides are provided. Also provided is a method for preparing Met-less NGF polypeptides.

REFERENCES:
patent: 4338397 (1982-07-01), Gilbert et al.
patent: 4757013 (1988-07-01), Inouye et al.
patent: 5235043 (1993-08-01), Collins et al.
Vigal et al, Mol. Gen. Genet. 231 (1991).
Oliver, Ann. Rev. Microbiol. 39 (1985).
Gennity et al., Signal Peptide Mutants of Escherichia Coli, Journal of Bioenergetics and Biomembranes, pp. 233-269, vol. 22, No. 3, 1990.
Goldstein et al., Enhancement of Protein Translocation across the Membrane by Specific Mutations in the Hydrophobic Region of the Signal Peptide, Journal of Bacteriology, pp. 1225-1231, vol. 172, No. 3, 1989.
Hallbook et al., Evolutionary Studies of the Nerve Growth Factor Family Reveal a Novel Member Abundantly Expressed in Xenopus Ovary, Neuron, pp. 845-848, vol. 6, May, 1991.
Lehnhardt et al., Modulation of the Effects of Mutations in the Basic Region of the OmpA Signal Peptide by the Mature Portion of the Protein, Journal of Biological Chemistry, pp. 10300-10303, vol. 263, No. 21, Jul. 1988.
Lehnhardt et al., The Differential Effect on Two Hybrid Proteins of Deletion Mutations within the Hydrophobic Region of the Escheria coli OmpA Signal Peptide, Journal of Biological Chemistry, pp. 1716-1719, vol. 262, No. 4, Feb. 1987.
Kaisho et al., Cloning and expression of a cDNA encoding a novel human neurotrophic factor, FEBS Letters, pp. 187-191, vol. 266, No. 1, 2, Jun. 1990.
Maisonpierre et al., Human and Rat Brain-Derived Neurotrophic Factor and Neurotrophin-3: Gene Structures, Distributions, and Chromosomal Localizations, Genomics 10, pp. 558-568, 1991.
Narhi et al., Comparison of the Biophysical Characteristics of Human Brian-derived Neurotrophic Factor, Neurotrophin-3, and Nerve Growth Factor, Journal of Biological Chemistry, pp. 13309-13317, vol. 268, No. 18, Jun. 1993.
Rosenthal et al., Primary Structure and Biological Activity of a Novel Human Neurotropic Factor, Neuron, pp. 767-773, vol. 4, May 1990.
Tanji et al., Effect of OmpA Signal Peptide Mutations on OmpA Secretion, Synthesis, and Assembly, Journal of Bacteriology, pp. 1997-2005, vol. 173, No. 6, Mar. 1991.

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