Modified oligonucleotides, their preparation and their use

Details Modified oligonucleotides, their preparation and their use Modified oligonucleotides, their preparation and their use

1995-11-06

1998-12-01

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2532, 536 243, C07H 1900, C07H 2102, C07H 2104

Patent

active

058441069

ABSTRACT:
Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents. Processes for preparing

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