Modified oligonucleotides, their preparation and their use

Details Modified oligonucleotides, their preparation and their use Modified oligonucleotides, their preparation and their use

1998-06-10

2000-05-23

Riley, Jezia

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 911, 435 912, 514 1, 514 44, 536 231, 536 243, 536 253, 536 2532, 536 271, 536 2711, 536 2712, 536 2713, C12Q 168, C07H 1900, C07H 2100, A01N 6100

Patent

active

060667206

ABSTRACT:
The invention relates to novel modified oligonucleotides which contain at least one 8-azapurine base and form more stable hybridization complexes with nucleic acids; To a process for their preparation, and to their use as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology, and as a pharmaceutical or diagnostic agent.

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