Modified oligonucleotides, their preparation and their use

Details Modified oligonucleotides, their preparation and their use Modified oligonucleotides, their preparation and their use

1998-08-31

2000-11-21

Riley, Jezia

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 241, 536 243, 536 253, 536 256, 536 245, 536 271, 536 2711, 536 2713, 435 6, 435 911, 435 912, 514 44, C07H 1900, C07H 2100, C07H 2102, C07H 2104, C12Q 168

Patent

active

061505102

ABSTRACT:
Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents. Processes for preparing them are provided.

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