Modified oligonucleotides and applications thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091100, C435S091200, C536S023100, C536S024300

Reexamination Certificate

active

07807376

ABSTRACT:
Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof.

REFERENCES:
patent: 7414118 (2008-08-01), Mullah et al.
patent: 7585649 (2009-09-01), Mullah et al.
Englisch et al. Agnew. Chem. Int. Ed. Engl. vol. 30, No. 6, Jun. 1991, pp. 613-722.

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